SITE SEARCH

Objectives

1. To provide a thorough knowledge of selected contemporary topics in molecular immunology. The emphasis will be on understand the mechanistic basis of processes that are central to the immune response and on understanding the approaches used to elucidate these mechanisms.
   
   
2. To learn how to critically evaluate primary literature.
   
   
3. To learn how to clearly present scientific information in written and oral formats.

Class Format

Background Presentation (30 minutes): The background presentation should be planned with the help of the primary faculty member for the class. The purpose of the background presentation is to summarize the important aspects of the area being covered during the class.

Paper Discussion (90 minutes): Three to four primary papers are assigned for each class. In some cases a review is also provided for background reading. The assigned papers (excluding reviews) will be covered in detail figure by figure and students will be expected to be able to present and discuss all of the figures. Figure presentations should generally adhere to the following format:

• State the question being asked in the figure.
  
  
• Describe the techniques used to address the question and any pertinent limitations of the techniques.
  
  
• Results and conclusions.
  
  
• Are the conclusions valid?

The primary faculty will be available during the week prior to the class to answer any questions regarding the papers or background presentation.

Grading: 25% Oral presentation, 25% research proposal, 50% class participation

Date	Speaker	Title
September 18, 2007	General Introduction
September 25, 2007	Primary Faculty: Wayne M. Yokoyama, M.D. Student Presenter: Julie Elliott	NK Cells 1-Jonjic_S_2006_JEM 2-Campbell_J_2007_JEM 3-Mandelboim_O_2007_Sci_miRNA
October 2, 2007	Primary Faculty: Barry Sleckman, MD, PhD Student Presenter: Sam Lam	V(D)J Recombination / Ig Class switch recombination Leiber Ise CSR AT CSRSH Rev CSR review RPA SH AT3
October 3, 2007 6:00-8:00 PM	Sleckman/White	Genetically manipulated mice
October 9, 2007	Primary Faculty: Chyi-Song Hsieh, M.D., Ph.D. Student Presenter: Winnie Lee	Regulatory T cells ignatowicz shevach preview treg and th17 science hayday-nature
October 10, 2007 6:00-8:00 PM	Swat / Miller	Flow Cytometry and Imaging Techniques
October 16, 2007	Primary Faculty: Paul Allen Student Presenter: Matthew Vogt	T Cell Recognition of Antigen 1-Irvine 2-Krogsgaard 3-Huse Review-Davis
October 23, 2007	Primary Faculty: Ken Murphy Student Presenter: Hyang Mi Lee/Sang Hun Lee	T Helper Cell development 1 - TGFbeta Stockinger 2 - RORgt Littman 3 - IL21 Dong 4 - Review Murphy
October 30, 2007	Primary Faculty: Steven Hedrick (Distinguished Immunology Speaker) Student Presenter: Margaret Young	Evolution of the Immune System - selective pressure from co-evolving pathogens Bio5272-Handout-Hedrick EvasionofHost[5] Hedrick-Vantage[5] Urchin-genome-DevBio Urchin-genome-Science Urchin-immune response UrchinImmune-PhysiolGen
November 6, 2007	Primary Faculty: Emil Unanue Student Presenter: Aaron Rapaport	Antigen presentation Adv Topic of 11_6_07[4] Homo-delarche-pancreas developm[4] Turley-Mathis[5] Unanue Final Manuscript (Immunity)[4]
November 13, 2007	Primary Faculty: Ted Hansen / Daved Fremont Student Presenter: Charles Rickert/Julia Warren	Immune Evasion hislop_2007 loureiro_2006pdf lybarger_2005 wang_2007
November 16, 2007	Grant Topics Due
November 20, 2007	Primary Faculty: Andrey Shaw Student Presenter: Holly Smith	Lymphocyte signaling sdarticle[2] 1031[2] ni1272[2]
November 27, 2007	Primary Faculty: Robert Schreiber, PhD Student Presenter: James Mohan	Tumor Immunology: Hopes and controversies Blankenstein nature06309_proof3 nature news and views Qin and Blankenstein JEM 195 Schreiber Response Shankaran Willimaky NV Willimsky_nature03954 Schreiber class notes - Nov 27th
December 4, 2007	Primary Faculty: Marco Colonna Student Presenter: Melissa Pak	How cells sense viruses NALP3_Tschopp Gout_Tschopp NAIP5_Swanson martinon-review
December 10, 2007	Grants Due
December 11, 2007	Primary Faculty: Debbie Lenschow Student Presenter: Jason Kennedy	Type I interferons Berland et al paper Christensen et al paper Marshak review Medzhitov review Pisitkun et al paper
December 18, 2007	Grant Study Sections

Faculty	Office	Phone	E-mail
Paul Allen, PhD	CSRB 7751	362-8758	pallen@wustl.edu
Marco Colonna, M.D.	West Building	747-1221	mcolonna@wustl.edu
Daved Fremont, Ph.D.	CSRB 7701	747-6547	fremont@wustl.edu
Ted Hansen, PhD	CSRB 8849	362-2716	hansen@wustl.edu
Chyi-Song Hsieh, M.D., Ph.D.	CSRB 6610	362-2214	chsieh@im.wustl.edu
Debbie Lenschow, M.D.		362-9224	dlenschow@pathology.wustl.edu
Mark Miller, Ph.D.	West 3710	362-3044	mmiller23@wustl.edu
Kenneth Murphy, MD, PhD	CSRB 7758	362-2009	kmurphy@wustl.edu
Robert Schreiber, PhD	CSRB 7749	362-8747	schreiber@wustl.edu
Andrey Shaw, MD	CSRB 7721	362-4614	ashaw@wustl.edu
Barry Sleckman, MD, PhD	West 1747	747-8235	sleckman@wustl.edu
Wojciech Swat, PhD	West 3710	747-8889	swat@wustl.edu
Emil Unanue, MD	West 3701	362-7440	unanue@wustl.edu
Wayne Yokoyama	CSRB 10058	362-9075	yokoyama@imgate.wustl.edu